Biologists at several startups are applying the latest advances in genetic engineering to the age-old problem of baldness, by creating new hair-forming cells that could restore a person’s ability to grow hair.

Some researchers tell MIT Technology Review they are using the techniques to grow human hair cells in their labs and even on animals. A startup called dNovo sent us a photograph of a mouse sprouting a dense clump of human hair—the result of a transplant of what the company says are human hair stem cells.

The company’s founder is Ernesto Lujan, a Stanford University-trained biologist. He says his company can produce the components of hair follicles by genetically “reprogramming” ordinary cells, like blood or fat. More work needs to be done, but Lujan is hopeful that the technology could eventually treat “the underlying cause of hair loss.”

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We’re born with all the hair follicles we’ll ever have—but aging, cancer, testosterone, bad genetic luck, even covid-19 can kill the stem cells inside them that make hair. Once these stem cells are gone—so is your hair. Lujan says his company can convert any cell directly into a hair stem cell by changing what patterns of genes are active in it.

“In biology, we now understand cells as a ‘state’” rather than a fixed identity, says Lujan. “And we can push cells from one state to another.” 

Reprogramming cells

The chance of replacing hair is one corner of a wider exploration of whether reprogramming technology can defeat the symptoms of aging. In August, MIT Technology Review reported on stealthy company, Altos Labs, that plans to explore whether people can be rejuvenated using reprogramming. Another startup, Conception, is trying to extend fertility by converting blood into human eggs.

A key breakthrough came in the early 2000s, when Japanese researchers hit on a simple formula to turn any type of tissue into powerful stem cells, similar to ones in an embryo. Imaginations ran wild. Scientists realized they could potentially manufacture limitless supplies of nearly any type of cell—say nerves or heart muscle.

In practice, though, the formula for producing specific cell types can prove elusive, and then there’s the problem of getting lab-grown cells back into the body. So far, there have been only a few demonstrations of reprogramming as a method to treat patients. Researchers in Japan tried transplanting retina cells into blind people. Then, last November, a US company, Vertex Pharmaceuticals, said it might have cured a man’s Type 1 diabetes after an infusion of programmed beta cells, the kind that respond to insulin.

The concept being pursued by startups is to collect ordinary cells from patients, say skin, then convert these into hair-forming cells. In addition to dNovo, a company called Stemson (its name is a portmanteau of stem cell and Samson) has raised $22.5 million including from the drug company AbbVie. Co-founder and CEO Geoff Hamilton says his company is transplanting reprogrammed cells onto the skin of mice and pigs to test the technology.

Both Hamilton and Lujan think there is a substantial market. About half of men undergo male-pattern baldness, some starting in their 20s. When women lose hair, it’s often a more general thinning, but no less a blow to a person’s self-image.

These companies are bringing high-tech biology to an industry known for illusions. There are plenty of bogus claims about both hair loss remedies and the potential of stem cells. “You’ve got to be aware of scam offerings,” Paul Knoepfler, a stem cell biologist at UC Davis, wrote in November.

A close up of a skin organoid that is covered with hair follicles. JIYOON LEE AND KARL KOEHLER, HARVARD MEDICAL SCHOOL

Tricky business

So is stem cell technology going to cure baldness or become the next false hope? Hamilton, Stemson’s founder, was invited to give the keynote at this year’s Global Hair Loss Summit, and says he tried to emphasize that the company still has plenty of research ahead of it. “We have seen

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By: Antonio Regalado
Title: Going bald? Lab-grown hair cells could be on the way
Sourced From: www.technologyreview.com/2022/01/18/1043751/bald-lab-grown-hair-cells/
Published Date: Tue, 18 Jan 2022 09:44:18 +0000

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