The 58-year-old man was blind, barely able to perceive whether it was day or night. After receiving gene therapy to add light-sensing molecules to one of his retinas, he could locate a notebook set on a table.
Scientists in Europe and the US are reporting today what they describe as the first successful use of optogenetics to improve a person’s vision. The feat involved introducing a gene from algae into the man’s retina.
“I think that a new field is being born,” Botond Roska, a professor at the University of Basel who led the research, said during a conference call with journalists.
In Nature Medicine, the authors describe how their patient lost his vision after being diagnosed 40 years ago with retinitis pigmentosa, a degenerative disease that destroys photoreceptors, the light-sensing cells in the retina.
The doctors employed gene therapy to add a light-sensing molecule to one of the man’s eyes. The gene they added, called chrimson, comes from a single-celled algae species that is able to sense sunlight and move toward it.
The idea of adding the gene, says Roska, is to engineer retina cells called ganglions so they are able to respond to light, sending visual signals to the brain.
The strategy, being funded by a French company called GenSight Biologics, requires patients to wear a set of electronic goggles that capture light contrasts in the environment and then project an image onto the retina at high intensity using the specific wavelength of yellow-orange light that triggers the chrimson molecule.
A blind patient treated with a novel form of gene therapy employs a set of goggles to try to count objects placed in his field of view. He is wearing an EEG cap so that researchers can measure his brain’s response to light.NATURE
According to José-Alain Sahel, a researcher at the University of Pittsburgh who played a chief role in the experiment and is a cofounder of GenSight, the blind man at first noticed no effect, but he gradually started reporting seeing shapes while wearing the goggles. Sahel describes the patient as “the first ever to benefit from optogenetics.”
With training, the man was able to perceive whether a notebook had been placed on a table in front of him. He could also count dark-colored cups set before him, although not always accurately.
Optogenetics is widely used in neuroscience experiments on animals, where the light-sensing molecules are added to brain cells. Then, using light pulses delivered via fiber-optic cables, researchers
By: Antonio Regalado
Title: A blind man can perceive objects after a gene from algae was added to his eye
Sourced From: www.technologyreview.com/2021/05/24/1025251/a-blind-man-can-perceive-objects-after-a-gene-from-algae-was-added-to-his-eye/
Published Date: Mon, 24 May 2021 15:00:00 +0000
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